1. DeBalsi KL, Goodman KD, Sommerville LJ, Mitchell MW, Lane BA, Evan AM, Kennedy, AD. Dried blood spots capture a wide range of metabolic pathways and biological changes associated with exercise. Metabolomics. 2025 Dec 22;22(1):14. https://pubmed.ncbi.nlm.nih.gov/41430033/
2. Oja KT, Ilisson M, Reinson K, Muru K, Reimand T, Peterson H, Fisherman D, Haller T, Kronberg J, Estonian Biobank Research Team, Wojcik MH, Kennedy AD, Sommerville LJ, Michelotti G, O'Donnell-Luria A, Oiglane-Shlik E, Pajusalu S, Ounap K. Exploratory analysis of epilepsy biomarkers using untargeted metabolomics across multiple cohorts. Front Neurol. 2025 Dec 1;16:1684456. https://pubmed.ncbi.nlm.nih.gov/41404459/
3. Dufford, MT, Fleischer, TC, Sommerville, LJ, Badsha, MB, Polpitiya, AD, Logan, J, Fox, AC, Rust, SR, Cox, CB, Garite, TJ, Boniface, JJ, Kearney, PE. “Clock proteins have the potential to improve term delivery date prediction: a proof-of-concept study” Life (Basel) 2025 Feb 3;15(2):224. https://pubmed.ncbi.nlm.nih.gov/40003633/
4. Karen L DeBalsi, John H Newman, Laura J Sommerville, John A Phillips 3rd, Rizwan Hamid, Joy Cogan, Joshua P Fessel, Anne M Evans, Undiagnosed Diseases Network, Adam D Kennedy. “A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old-Male” Metabolites2023 Mar 8;13(3):399. https://pubmed.ncbi.nlm.nih.gov/36984839/
5. Ruifang Li-Gao, Kirk Grubbs, Alain Bertoni, Kristi L Hoffman, Joseph F Petrosino, Gautam Ramesh, Martin Wu, Jerome I Rotter, Yii-Der Ida Chen, Anne M Evans, Richard J Robinson, Laura J Sommerville, Dennis Moor-Kanamori, Mark O Goodarzi, Gregory A Michelotti, Patrician A Sheridan. “The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)” Metabolites 2022 Aug 25;12(9):787. https://pubmed.ncbi.nlm.nih.gov/36144194/
6. Nandi S, Sommerville L, Erb M, Freytes D, Hoffman M, Monroe D, Brown A. “Platelet-like particles improve clot properties in a hemophilic model of wound healing” J Colloid Interface Sci 2020 Oct 1;557:406-418. https://pubmed.ncbi.nlm.nih.gov/32502667/
7. Nimjee SM, Dornbos D 3rd, Pitoc GA, Wheeler DG, Layzer JM, Venetos N, Huttinger A, Talentino SE, Musgrave NJ, Moofy H, Rempel RE, Jones C, Carlisle K, Wilson J, Bratton C, Joseph ME, Khan S, Hoffman MR, Sommerville L, Becker RC, Zweier JL, Sullenger BA. “Preclinical development of a vWF aptamer to limit thrombosis and engender arterial recanalization of occluded vessels” Mol Ther 2019 Jul 3;27(7):1228-1241. https://pubmed.ncbi.nlm.nih.gov/30987839/
8. Sommerville LJ, Gorman K, Snyder S, Monroe D, Hoffman M. “A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes” J Thromb Haemost 2019 Apr;17(4):670-680. https://pubmed.ncbi.nlm.nih.gov/30698330/
9. D’Costa S, Ayyadurai S, Gibson AJ, Mackey E, Rajput M, Sommerville LJ, Wilson N, Li Y, Kubat E, Kumar A, Subramanian H, Bhargava A, Moeser AJ. “Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability” J Allergy Clin Immunol 2019 May;143(5):1865-1877. https://pubmed.ncbi.nlm.nih.gov/30439403/
10. Ayyadurai S, Gibson A, D’Costa S, Overman E, Sommerville L, Poopal A, Mackey E, Li Y, Moeser A. “Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology” J Leukoc Biol 2017 Dec;102(6):1299-1312. https://pubmed.ncbi.nlm.nih.gov/28684600/
11. Muthusamy N, Sommerville L, Moeser A, Stumpo D, Sannes P, Adler K, Blackshear P, Weimer J, Ghashghaei HT. “MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging” Aging Cell 2015 Oct;14(5):764-73. https://pubmed.ncbi.nlm.nih.gov/26010231/
12. Sommerville L, Kelemen S, Ellison S, England R, Autieri M. “Increased atherosclerosis and vascular smooth muscle cell activation in AIF-1 transgenic mice fed a high-fat diet” Atherosclerosis 2012 Jan;220(1):45-52. https://pubmed.ncbi.nlm.nih.gov/21862018/
13. Jacquet BV, Muthusamy N, Sommerville LJ, Xiao G, Liang H, Zhang Y, Holtzman MJ, Ghashghaei HT. “Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb” J Neurosci 2011 Jun 22l31(55):9368-82. https://pubmed.ncbi.nlm.nih.gov/21697387/
14. Hinoki A, Kimura K, Higuchi S, Eguchi K, Takaguri A, Ishimaru K, Frand GD, Gerthoffer WT, Sommerville LJ, Autieri MV, Eguchi S. “p21-activated kinase 1 participates in vascular remodeling in vitro and in vivo” Hypertension 2010 Jan;55(1):161-5. https://pubmed.ncbi.nlm.nih.gov/19901155/
15. Sommerville L, Xian C, Kelemen S, Eguchi S, Autieri M. “Inhibition of Allograft Inflammatory Factor-1 expression reduces development of neointimal hyperplasia and p38 kinase activity” Cardiovasc Res 2009 Jan 1;81(1):206-15. https://pubmed.ncbi.nlm.nih.gov/18779232/
16. Tian Y, Sommerville LJ, Cuneo A, Kelemen SE, Autieri MV. “Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia” Am J Pathol 2008 Sep;173(3):901-9. https://pubmed.ncbi.nlm.nih.gov/18669613/
17. Sommerville L, Kelemen S, Autieri M. “Increased smooth muscle cell activation and neointima formation in response to injury in AIF-1 transgenic mice” Arterioscler Thromb Vasc Biol 2008 Jan;28(1):47-53. https://pubmed.ncbi.nlm.nih.gov/17991871/
1. Pescatore R, et al. Analytical validation of a serum biomarker signature for detection of early-stage pancreatic ductal adenocarcinoma. Diagnostics (Basel). 2025 Dec 12;15(24):3177. https://pubmed.ncbi.nlm.nih.gov/41464180/
2. Polanco PM, et. al. Confirmatory clinical validation of a serum-based biomarker signature for detection of early-stage pancreatic ductal adenocarcinoma. Curr Oncol. 2025 Nov 13;32(11):638. https://pubmed.ncbi.nlm.nih.gov/41294700/
3. Lucas AL, et. al. Validation of a serum-based biomarker signature for detection of early-stage pancreatic ductal adenocarcinoma. Gastroenterology. 2025 Oct 27:S0016-5085(25)05976-1. https://pubmed.ncbi.nlm.nih.gov/41143761/
4. Palma NA, et al. A high performing biomarker signature for detecting early-stage pancreatic ductal adenocarcinoma. Cancers (Basel). 2025 Jun 2;17(11):1866. https://pubmed.ncbi.nlm.nih.gov/40507347/
1. A metabolomics-based laboratory developed test to better predict and monitor progression of type 1 diabetes. https://reporter.nih.gov/project-details/10921956
2. A metabolomics-based laboratory developed test to improve the diagnostic precision of polycystic ovary syndrome. https://reporter.nih.gov/project-details/10820801
3. Rapid point-of-care molecular test for HCV VL. https://reporter.nih.gov/project-details/10330833
4. System for unitary automation of library preparation. https://reporter.nih.gov/project-details/10395282
5. Improving extraction success of FFPE samples with automated and reliable microfluidic sample preparation. https://reporter.nih.gov/project-details/10547272
1. eBook: Metabolomics meets proteomics. https://www.metabolon.com/wp-content/uploads/2025/04/03-2025-MTB-eBook-Proteomics-2.pdf
2. eBook: Guide to the exposome (Chapters 3-5). https://www.metabolon.com/wp-content/uploads/2025/11/10-2025-MTB-eBook-Exposome-Guide-1.pdf
3. Blog: Metabolomics for cell and gene therapy. https://www.metabolon.com/blog/metabolomics-cell-gene-therapy/
4. Blog: Part II: Metabolomics for cell and gene therapy product development. https://www.metabolon.com/blog/metabolomics-cell-gene-therapy-product-development/
5. Blog: A brief history of metabolomics. https://www.metabolon.com/blog/advancing-metabolomics-with-metabolon/
6. Case Study: Metabolomics provides insight into the pathology of sudden infant death syndrome. https://www.metabolon.com/resources/case-studies/metabolomics-provides-insight-into-the-pathology-of-sudden-infant-death-syndrome-and-identifies-biomarker-candidates/
7. Case Study: Integrating metabolomics and GWAS to identify rare variant metabolite associations. https://www.metabolon.com/resources/case-studies/metabolomics-gwas-variant-metabolite-associations/
8. Case Study: Metabolomics reveals beneficial changes to metabolite profiles during diabetes remission. https://www.metabolon.com/resources/case-studies/diabetes-remission/